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KMID : 0381920060360020131
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Korean Journal of Microscopy
2006 Volume.36 No. 2 p.131 ~ p.140
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A Study on the Localization of Neurofascin in the Myelinated Rat Sciatic Nerve Fibers
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Chang Byung-Hwa
You Kwan-Hee
Cho Ik-Hyun
Lee Jong-Hwan
Bae Chun-Sik
Park Chang-Hyun
Han Jeong-Mi
Choe Nong-Hoon
Chang Byung-Joon
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Abstract
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Neurofascin, one of the members of L1CAM, has been known to have some important roles during the development of nerve fibers. In order to investigate the role of neurofascin associated with the myelination of peripheral nerves, the localization of neurofascin in myelinated rat sciatic nerve fibers was studied with the immuno-fluorescence and immuno-electron microscopy and the results are as follows; 1. According to the myelination is going on, neurofascin localization was dramatically changed in the sciatic nerve fibers. 2. In the myelinated fibers, neurofascin was weakly localized along the axolemma at the node of Ranvier. 3. Neurofascin was also apparantly localized at the non-compact area of Schwann cell membrane such as paranodal loop, Schmidt-Lantermann incisure, inner & outer mesaxons in the myelinated fibers. From the above results, neurofascin is likely to have a role to sustain the ideal gap of apposing membranes of Schwann cell, so it may enable to materials transport in the myelin sheath.
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KEYWORD
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Immunocytochemistry, Neurofascin, Sciatic nerve
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